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Low-dose naltrexone (LDN) has been used as an off-label treatment for pain and inflammation in multiple sclerosis, Crohn's disease, and fibromyalgia (FM) for several years . Naltrexone (NLX) is marketed as an additional therapy for the prevention of relapse in patients with previous abuse of opioids or alcohol [ 2 ].. What is low dose naltrexone? Low dose naltrexone (LDN) means taking a dose of naltrexone that is up to one-tenth, or 10%, of the dose that is usually taken for opioid addiction. A low dose of naltrexone is approximately 4.5mg of naltrexone a day compared with the usual dosage of naltrexone for opioid addiction which is 50mg to 100mg a day.


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