The normal range of 25-hydroxy vitamin D is measured as nanograms per milliliter (ng/mL). Many experts recommend a level between 20 and 40 ng/mL. Others recommend a level between 30 and 50 ng/mL. The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories.. The optimal serum 25(OH)D concentration for skeletal health is controversial. Based upon the trials of vitamin D supplementation and National Academy of Medicine (NAM), formerly called the Institute of Medicine (IOM), systematic review , we favor maintaining the serum 25(OH)D concentration between 20 and 40 ng/mL (50 to 100 nmol/L). Experts.

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Many tissues have vitamin D receptors, and some convert 25 (OH)D to 1,25 (OH)2D. In foods and dietary supplements, vitamin D has two main forms, D 2 (ergocalciferol) and D 3 (cholecalciferol), that differ chemically only in their side-chain structures. Both forms are well absorbed in the small intestine.. Vitamin D production in the skin under the influence of sunlight (UVB) is maximized at levels of sunlight exposure that do not burn the skin. Further metabolism of vitamin D to its major circulating form (25(OH)D) and hormonal form (1,25(OH)2D) takes place in the liver and kidney, respectively, but also in other tissues where the 1,25(OH)2D produced serves a paracrine/autocrine function.