Solubility is a critical physical property of organic compounds in drug development, e.g., availability, distribution, metabolism, excretion and toxicity (ADMET) 1,2, protein engineering 3,4,5.. solubility in 10 organic solvents at 298.15, 323.15, and 373.15 K, and partially at pressures of up to 14 MPa. Literature data on the solubility of hydrogen in liquids has
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The solvatochromicity of established solvatochromic UV/Vis probes, which appear to be sensitive to the so-called hydrogen bond donor (HBD) property of the solvent, is analysed using the hydroxyl group density of alcoholic solvents D HBD as a physical parameter in comparison to the pKa, the chemical benchmark for acidity. Reichardt's dye B30, Kosowers Z-indicator 1-ethyl-4-(methoxycarbonyl.. The solubility of hydrogen in the organic solvents is generally very small and therefore Henry's constant is a valuable descriptor of the solubility [20]. The binary systems of hydrogen with n.
